Immunologic “hot” and “excluded” HNSCCs are associated with better overall survival than “cold” HNSCC patients ( p < 0.05). Results: Investigating tumor immune cell patterns, we found significant differences in survival rates. H&E whole slides from resection specimen ( n = 289) were categorized according to their immune cell infiltrate as “hot,” “cold,” or “excluded.”
Methods: Tissue microarrays were assembled from tumor tissue samples and were complemented with comprehensive clinicopathological data of n = 419 patients. Therefore, it is necessary to further stratify HNSCC, especially with recent advances in tumor immunology. Past therapeutic advances have not significantly improved HNSCC prognosis.
Background: Head and neck squamous cell carcinoma (HNSCC) represents a common cancer worldwide.
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